Investigating how body fat affects heart disease risk and lipid levels
Multi-omic investigation of the adiposity-lipid intersection and its role in cardiovascular disease risk
This study is looking at how extra body fat affects heart disease and whether anti-obesity medications can help lower that risk, using a lot of health data to see how body fat interacts with things like cholesterol and blood pressure over time.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10948413 on NIH RePORTER |
What this research studies
This research explores the relationship between excess body fat and heart disease, focusing on how anti-obesity medications (AOMs) may reduce heart disease risk. By analyzing large datasets that include genetic, clinical, and multi-omic data, the study aims to understand how body fat influences blood lipid levels and other risk factors for heart disease. The research will measure the interaction between genetic variants and adiposity, evaluate the impact of adipose tissue volume on lipid levels over time, and assess how other factors like blood pressure and blood sugar levels mediate the effects of AOMs on heart disease risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with excess body fat who are at risk for heart disease and may be considering anti-obesity medications.
Not a fit: Patients who are not overweight or do not have cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of how weight loss and AOMs contribute to heart disease risk reduction, potentially informing better treatment strategies.
How similar studies have performed: Previous research has shown that understanding the biological mechanisms linking obesity and heart disease can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dron, Jacqueline Shirley — Massachusetts General Hospital
- Study coordinator: Dron, Jacqueline Shirley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.