Investigating how body fat affects colorectal cancer outcomes
Official title: Body composition and adiposity-associated thromboinflammation in colorectal cancer prognosis
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11082462 · Data updated 2026-11-12
This study is looking at how being overweight might affect the outcomes of colorectal cancer by using special technology to get a better picture of body fat and muscle, and it hopes to find new ways to help treat patients based on their unique needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $664,642 |
| NIH project number | 5R01CA276496-02 |
| Project ID | NIH-11082462 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer who also have obesity or are overweight.
✕Less likely to help
Patients without colorectal cancer or those who are not classified as obese may not benefit from this research.
What this research studies
This research explores the connection between obesity and colorectal cancer prognosis by examining body composition beyond traditional measures like BMI. It utilizes advanced artificial intelligence to analyze CT scans for precise measurements of fat distribution and muscle mass. The study also investigates a new biological pathway called thromboinflammation, which may influence cancer progression in obese patients. By understanding these factors, the research aims to improve treatment strategies tailored to individual patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for colorectal cancer patients with obesity.
How similar studies have gone: Previous research has shown promising results in using advanced imaging and biological pathways to improve cancer treatment outcomes, suggesting this approach could be impactful.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Byrd, Doratha Armenthus — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Byrd, Doratha Armenthus
Related research
Other NIH-funded projects on the same topics.
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Body fat, muscle, and clot-related inflammation in colorectal cancer outcomes
This project uses AI analysis of CT scans plus blood and tumor tests to link patterns of fat and muscle with clotting-related inflammation that may change outcomes for people with colorectal cancer.
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Colorectal cancer prognosis through a broad, collaborative study
A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.
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ColoCare: following people with colorectal cancer to find blood and microbiome signs
This project follows people newly diagnosed with colorectal cancer and collects blood, stool, urine, and tumor samples to find markers that help predict outcomes.
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Body fats and immune signals shaping bladder cancer outlook
This study will look at how body composition and immune/inflammatory states at diagnosis relate to the outlook for people with non-muscle-invasive bladder cancer.
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ColoCare: colorectal cancer survivorship and prognosis
This project follows people newly diagnosed with colorectal cancer to find blood, tissue, stool, and lifestyle markers that help predict outcomes.
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ColoCare: tracking health and recovery after colorectal cancer
This project follows people with colorectal cancer over time to find blood, stool, and tissue signs that predict recovery and long-term outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.