Investigating how BMP signaling affects tracheal cartilage development to prevent airway collapse in children
Temporal regulation of BMP signaling in patterning the tracheal cartilage and pharmacological approaches to prevent tracheomalacia
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11030761
This study is looking at how a specific protein helps form the cartilage in the windpipe, which is important for keeping kids' airways strong, and it hopes to find new treatments that could help children with tracheomalacia without needing surgery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11030761 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Bone Morphogenetic Protein (BMP) signaling in the development of tracheal cartilage, which is crucial for maintaining airway integrity in children. By studying animal models, the researchers aim to uncover the mechanisms that regulate BMP signaling during tracheal cartilage formation. The ultimate goal is to identify pharmacological approaches that could serve as alternative treatments to surgery for children suffering from tracheomalacia, a condition characterized by weakened tracheal support. This could lead to new therapies that improve airway function and reduce the need for invasive procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with tracheomalacia or related airway diseases.
Not a fit: Patients with tracheomalacia due to non-congenital causes or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide non-surgical treatment options for children with tracheomalacia, improving their quality of life and reducing healthcare costs.
How similar studies have performed: Previous research has shown promising results in understanding BMP signaling in cartilage development, suggesting that this approach could lead to significant advancements in treating airway diseases.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MISHINA, YUJI — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: MISHINA, YUJI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway Disease