Investigating how BMP signaling affects the regeneration of pancreatic cells in diabetes.
Official title: BMP signaling and regenerative plasticity: Correlating dynamic scRNAseq and real-time anatomical remodeling in T1D pancreatic slices
Funded at University of Miami School of Medicine · NIH-11005401 · Data updated 2026-11-12
This study is looking at how certain signals can help pancreatic cells heal and grow, which could lead to better treatments for diabetes, and it's designed for anyone interested in understanding how these cells work over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | January 2, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $513,083 |
| NIH project number | 5R01DK138210-02 |
| Project ID | NIH-11005401 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with adult-onset diabetes.
✕Less likely to help
Patients with type 1 diabetes who are under 21 years old or those who do not have adult-onset diabetes may not benefit from this research.
What this research studies
This research explores the dynamic changes in human pancreatic cells, particularly focusing on how BMP signaling can influence their regeneration. By using a novel technique called Dynamic SliceSeq, researchers will track the behavior of pancreatic slices over time, allowing them to observe how different cell types interact and change in response to treatment. This approach aims to provide a clearer understanding of pancreatic plasticity at the single-cell level, which could lead to new insights into diabetes treatment.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance pancreatic regeneration and improve outcomes for patients with diabetes.
How similar studies have gone: This research builds on previous studies that have shown promise in understanding pancreatic cell behavior, but the specific approach of using Dynamic SliceSeq is novel and untested.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Dominguez-Bendala, Juan — University of Miami School of Medicine
- Study coordinator: Dominguez-Bendala, Juan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.