Investigating how blood vessel problems affect lung healing and fibrosis
Targeting vascular dysfunction to promote lung repair and fibrosis resolution
This study is looking at how problems with blood vessels might make idiopathic pulmonary fibrosis (IPF) worse, especially in older adults, and it hopes to find new ways to help improve lung health by exploring potential treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11062422 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of vascular dysfunction in idiopathic pulmonary fibrosis (IPF), a severe lung disease that primarily affects older adults. By analyzing endothelial cells from both young and aged mice, the study aims to uncover how changes in blood vessels contribute to the progression of lung fibrosis. The researchers will use advanced techniques, including genetic manipulation and pharmacological interventions, to explore potential therapeutic targets that could improve lung repair mechanisms. This work could lead to new strategies for treating IPF by addressing the underlying vascular issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with idiopathic pulmonary fibrosis or those experiencing related lung issues.
Not a fit: Patients with early-stage lung diseases or those not diagnosed with idiopathic pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance lung repair and reduce fibrosis in patients with IPF.
How similar studies have performed: Previous research has shown promising results in targeting vascular dysfunction in other diseases, suggesting potential for success in this novel approach to IPF.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Ligresti, Giovanni — Boston University Medical Campus
- Study coordinator: Ligresti, Giovanni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.