Investigating how blood vessel health and inflammation affect Alzheimer's in adults with Down syndrome
Official title: Synergistic contributions of cerebrovascular disease and neuroinflammation to Alzheimer's disease in adults with Down syndrome
Funded at Columbia University Health Sciences · NIH-10998809 · Data updated 2026-11-12
This study is looking at how blood vessel problems and inflammation in the brain might affect Alzheimer's disease in adults with Down syndrome, hoping to find helpful information for better treatments and prevention.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AG090091-01 |
| Project ID | NIH-10998809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with Down syndrome who are experiencing or at risk for Alzheimer's disease.
✕Less likely to help
Patients without Down syndrome or those who do not exhibit symptoms of Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between cerebrovascular disease and neuroinflammation in the context of Alzheimer's disease (AD) among adults with Down syndrome (DS). It aims to explore how these factors contribute to the progression of AD and cognitive decline. By examining postmortem brain tissue and utilizing data from the Alzheimer’s Disease Biomarker Consortium – Down Syndrome, the study seeks to uncover critical insights that could inform treatment and prevention strategies. The findings may also have implications for the broader population affected by Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for Alzheimer's disease in individuals with Down syndrome.
How similar studies have gone: Previous research has shown promising results in understanding Alzheimer's disease through similar approaches, particularly in populations with genetic predispositions.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Edwards, Natalie Catherine — Columbia University Health Sciences
- Study coordinator: Edwards, Natalie Catherine
Related research
Other NIH-funded projects on the same topics.
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DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s
A smartphone-based cognitive test is being developed and tested for people with Down syndrome who may develop Alzheimer’s disease, to track changes quietly in daily life.
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Remote monitoring of Alzheimer’s changes in adults with Down syndrome
A study tests remote (at-home) ways to track Alzheimer’s-related thinking changes in adults with Down syndrome.
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How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome
Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.
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DS-ARC: A smartphone-based cognitive test for Down syndrome–associated Alzheimer’s disease
A smartphone-based cognitive test will be developed and tested to help detect early signs of dementia in adults with Down syndrome.
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DS-ARC: A smartphone-based cognitive test for Down syndrome-associated Alzheimer's disease
A new smartphone app will measure day-to-day thinking changes in adults with Down syndrome who may develop Alzheimer’s disease, helping catch early signs in a convenient, real-world way.
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DS-ARC: A Remote Digital Cognitive Test for Down Syndrome-Related Alzheimer’s Disease
A smartphone-based cognitive test is being developed to help people with Down syndrome who are at risk for Alzheimer’s disease understand and track early brain changes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.