Investigating how blood vessel health and inflammation affect Alzheimer's in adults with Down syndrome
Synergistic contributions of cerebrovascular disease and neuroinflammation to Alzheimer's disease in adults with Down syndrome
This study is looking at how blood vessel problems and inflammation in the brain might affect Alzheimer's disease in adults with Down syndrome, hoping to find helpful information for better treatments and prevention.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10998809 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between cerebrovascular disease and neuroinflammation in the context of Alzheimer's disease (AD) among adults with Down syndrome (DS). It aims to explore how these factors contribute to the progression of AD and cognitive decline. By examining postmortem brain tissue and utilizing data from the Alzheimer’s Disease Biomarker Consortium – Down Syndrome, the study seeks to uncover critical insights that could inform treatment and prevention strategies. The findings may also have implications for the broader population affected by Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down syndrome who are experiencing or at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who do not exhibit symptoms of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding Alzheimer's disease through similar approaches, particularly in populations with genetic predispositions.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Edwards, Natalie Catherine — Columbia University Health Sciences
- Study coordinator: Edwards, Natalie Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.