Investigating how blood vessel health affects brain degeneration and dementia.
Common mechanistic biomarkers of vascular and neuro-degeneration
This study is looking at how stiff blood vessels might affect memory and thinking skills, especially in people with Alzheimer's, by checking blood samples and brain scans over time to see how these changes relate to brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11001998 on NIH RePORTER |
What this research studies
This research explores the connection between arterial stiffness, a marker of vascular aging, and its impact on cognitive decline and dementia, particularly Alzheimer's disease. By analyzing plasma biomarkers and using advanced imaging techniques, the study aims to understand how changes in blood vessel health relate to brain degeneration. The research will also investigate genetic factors in immune cells that may influence both vascular and neurodegenerative processes. Patients may be monitored over time to assess changes in these biomarkers and their relationship to cognitive function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for dementia, particularly those with signs of vascular aging or cognitive decline.
Not a fit: Patients with no signs of vascular issues or cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating dementia by targeting vascular health.
How similar studies have performed: Previous research has shown promising results linking vascular health to cognitive outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Liu, Yongmei — Duke University
- Study coordinator: Liu, Yongmei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.