Investigating how blood vessel function in the hippocampus affects memory and cognitive decline in older adults with high blood pressure.
The Role of the Hippocampal Vasculature in Vascular Cognitive Impairment and Dementia
['FUNDING_R01'] · STATE UNIVERSITY OF NY,BINGHAMTON · NIH-11073094
This study is looking at how high blood pressure affects tiny blood vessels in the part of the brain that helps with memory and learning, to see how these changes might lead to memory problems as we get older, and it’s for older adults who want to understand more about their brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NY,BINGHAMTON (nih funded) |
| Locations | 1 site (BINGHAMTON, UNITED STATES) |
| Trial ID | NIH-11073094 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the impact of chronic hypertension on the small blood vessels in the hippocampus, a brain region crucial for memory and learning. The study aims to explore how these blood vessels, known as hippocampal arterioles, change in function as people age and how these changes may lead to vascular cognitive impairment and dementia. By examining the relationship between blood flow, vessel function, and cognitive performance, the research seeks to uncover mechanisms that could help prevent or treat memory decline in older adults. Patients may be involved in assessments that evaluate their cognitive abilities and vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have chronic hypertension and are experiencing cognitive changes.
Not a fit: Patients who do not have hypertension or significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline and dementia in older adults with hypertension.
How similar studies have performed: Previous research has indicated that vascular health is closely linked to cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
BINGHAMTON, UNITED STATES
- STATE UNIVERSITY OF NY,BINGHAMTON — BINGHAMTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAPMAN, ABBIE C — STATE UNIVERSITY OF NY,BINGHAMTON
- Study coordinator: CHAPMAN, ABBIE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.