Investigating how blood vessel function affects dementia in older adults
Role of Endothelial K+ Channels in Age-Related Dementia
['FUNDING_R01'] · LOMA LINDA UNIVERSITY · NIH-11089456
This study is looking at how problems with blood vessels in the brain might lead to memory issues as we get older, like in Alzheimer's disease, and it’s using mice to find out how these blood flow problems develop, which could help us discover new ways to treat or prevent dementia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOMA LINDA UNIVERSITY (nih funded) |
| Locations | 1 site (Loma Linda, UNITED STATES) |
| Trial ID | NIH-11089456 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how dysfunction in the blood vessels of the brain contributes to age-related cognitive disorders like Alzheimer's disease. By studying mouse models, the researchers aim to clarify the mechanisms by which blood flow issues arise and worsen with age and disease progression. The study will explore specific potassium channels in endothelial cells that play a crucial role in regulating blood flow to the brain. This comprehensive approach may help identify new targets for treatment and prevention strategies for dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing cognitive decline or are at risk for Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without any signs of cognitive decline are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve blood flow in the brain and potentially slow down or prevent the progression of dementia in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of blood vessel function in dementia, indicating that this approach could yield valuable insights.
Where this research is happening
Loma Linda, UNITED STATES
- LOMA LINDA UNIVERSITY — Loma Linda, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEHRINGER, ERIK J. — LOMA LINDA UNIVERSITY
- Study coordinator: BEHRINGER, ERIK J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.