Investigating how blood vessel formation affects bone tissue engineering
Endothelial cell specification at the osteogenic and angiogenic interface in cranial bone tissue engineering
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-10839815
This study is looking at how to help bones heal better after injuries or illnesses by figuring out how to grow more blood vessels in new bone tissue, which could lead to improved recovery for patients needing bone reconstruction surgeries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10839815 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the healing of bone loss caused by tumors, trauma, or infections by enhancing the formation of blood vessels in engineered bone tissue. It aims to understand how endothelial cells, which line blood vessels, develop and function in the context of bone repair. By studying the interaction between bone and blood vessel formation, the research seeks to identify ways to improve the vascularization of engineered bone constructs, which is crucial for their long-term success. Patients may benefit from advancements in techniques that could lead to better outcomes in bone reconstruction surgeries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals facing bone loss due to tumors, trauma, or infections, particularly those requiring craniomaxillofacial procedures.
Not a fit: Patients with stable bone conditions or those not requiring surgical intervention for bone loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients requiring bone reconstruction, resulting in improved healing and reduced complications.
How similar studies have performed: Other research has shown promise in enhancing vascularization in tissue engineering, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, XINPING — UNIVERSITY OF ROCHESTER
- Study coordinator: ZHANG, XINPING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.