Investigating how blood vessel dysfunction contributes to Alzheimer's disease
Contribution of endothelin 1 mediated ischemic vascular dysfunction to Alzheimer's disease
This study is looking at how issues with blood flow in the brain might contribute to memory problems in people with Alzheimer's disease, and it aims to find new ways to help prevent or treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10995783 on NIH RePORTER |
What this research studies
This research focuses on understanding how problems with blood flow in the brain may lead to cognitive decline in Alzheimer's disease (AD). It examines the relationship between neurovascular coupling, which is the process that increases blood flow in response to brain activity, and the presence of amyloid beta, a protein associated with AD. By studying animal models, the research aims to uncover the mechanisms behind vascular dysfunction and its impact on brain health over time. The findings could help identify new targets for treatment and prevention strategies for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or related dementias.
Not a fit: Patients with non-Alzheimer's related cognitive impairments or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve blood flow in the brain and slow down cognitive decline in Alzheimer's patients.
How similar studies have performed: Previous studies have shown that addressing vascular dysfunction can improve outcomes in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Woodruff, Simone — Oregon Health & Science University
- Study coordinator: Woodruff, Simone
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.