Investigating how blood vessel changes contribute to Alzheimer's disease
Microvascular Stress as a Pathway to Neurodegeneration in Alzheimer's
This study is looking at how problems with tiny blood vessels in the brain might contribute to Alzheimer's disease, focusing on when these issues happen and how they affect brain health, so we can better understand the disease and find new ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11014355 on NIH RePORTER |
What this research studies
This research explores the role of microvascular stress in the development of Alzheimer's disease, particularly how changes in blood flow and the blood-brain barrier may lead to cognitive decline. By examining human tissue samples and mouse models, the study aims to identify when and where microvascular stress occurs in relation to amyloid beta accumulation. The researchers will also investigate how this stress affects the blood-brain barrier's function and will manipulate gene expression in endothelial cells to understand the mechanisms involved. This comprehensive approach seeks to provide insights into the vascular contributions to Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing early signs of cognitive impairment or have a diagnosis of Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting microvascular health to slow or prevent cognitive decline in Alzheimer's patients.
How similar studies have performed: Previous research has indicated that targeting vascular health may improve outcomes in Alzheimer's disease, suggesting that this approach has potential based on earlier findings.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bennett, Rachel Elise — Massachusetts General Hospital
- Study coordinator: Bennett, Rachel Elise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.