Investigating how blood vessel cells contribute to brain amyloid buildup in Alzheimer's disease.
Role of endothelium in pathogenesis of cerebral amyloid angiopathy
This study is looking at how certain cells in your blood vessels might contribute to a brain condition called cerebral amyloid angiopathy, which is often linked to Alzheimer's disease, to help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10864954 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of blood vessel cells in the development of cerebral amyloid angiopathy (CAA), a condition that often overlaps with Alzheimer's disease. By studying how amyloid-β accumulates in the walls of brain blood vessels, researchers aim to uncover the molecular mechanisms that lead to cognitive decline. The project utilizes advanced techniques such as next-generation sequencing and genetically modified mouse models to explore these processes. Patients with CAA may benefit from insights gained through this research, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cerebral amyloid angiopathy or Alzheimer's disease, particularly those experiencing cognitive decline.
Not a fit: Patients with other forms of dementia not related to amyloid pathology may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for patients suffering from cerebral amyloid angiopathy and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of amyloid-β in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Katusic, Zvonimir S — Mayo Clinic Rochester
- Study coordinator: Katusic, Zvonimir S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.