Investigating how blood vessel cells affect hearing function
The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function
This study is looking at special cells in the inner ear that help keep blood flowing properly, to see how problems with these cells might lead to hearing loss, especially as we age or due to genetics, with the hope of finding new ways to help people with hearing issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10763809 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specialized cells called pericytes, which are crucial for maintaining healthy blood flow in the cochlea, the part of the inner ear responsible for hearing. The study aims to explore how pericyte-related vascular issues contribute to various types of hearing loss, including those associated with aging and genetic factors. By employing advanced techniques, the researchers will investigate the mechanisms behind pericyte function and their impact on hearing health. The findings could lead to new treatment options for individuals suffering from hearing loss due to vascular deficiencies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old experiencing hearing loss, particularly those with age-related or genetic conditions.
Not a fit: Patients with hearing loss not related to vascular issues or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new clinical options for treating hearing loss related to aging, noise exposure, and genetic factors.
How similar studies have performed: Other research has shown promising results in understanding the role of vascular health in hearing function, suggesting that this approach could lead to significant advancements.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Shi, Xiaorui — Oregon Health & Science University
- Study coordinator: Shi, Xiaorui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.