Investigating how blood vessel and immune interactions contribute to Alzheimer's disease and related conditions
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathology
This study is looking at how the health of blood vessels in the brain and the immune system are connected, especially in people with Alzheimer's disease, to find out how a protein called amyloid-β affects brain function and memory, with the hope of discovering new ways to improve treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11022861 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex relationship between blood vessel health and immune responses in the brain, particularly in the context of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). By examining how amyloid-β (Aβ) accumulates in blood vessels and affects brain function, the study aims to uncover the underlying mechanisms that contribute to cognitive decline. The research employs advanced techniques, including single-cell genomics, to analyze human brain tissue and animal models, providing insights into how these processes can be targeted for better treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those with the APOE4 genotype or signs of cerebral amyloid angiopathy.
Not a fit: Patients without Alzheimer's disease or those who do not exhibit symptoms related to amyloid deposition in the brain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the vascular and immune mechanisms in Alzheimer's disease, but this specific approach using single-cell genomics in human tissue is relatively novel.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Yang, Andrew Chris — J. David Gladstone Institutes
- Study coordinator: Yang, Andrew Chris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.