Investigating how blood stem cells behave in their bone marrow environment
Intravital analysis of hematopoietic stem cells in their bone marrow niche - Resubmission - 1
This study is looking at how blood-making stem cells in the bone marrow work and interact with other cells, which could help improve treatments like bone marrow transplants for older patients or those with inflammation, making it easier for them to recover and produce healthy blood cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10913423 on NIH RePORTER |
What this research studies
This research focuses on understanding the behavior of hematopoietic stem cells (HSC) within the bone marrow, which is crucial for blood cell production. By using advanced imaging techniques, researchers will observe live HSC and their interactions with surrounding cells in real-time. The study aims to uncover how these stem cells can be mobilized from the bone marrow to improve treatments like bone marrow transplants, especially in older patients or those with inflammatory conditions. This could lead to better strategies for enhancing blood cell regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals with conditions affecting their blood cell production.
Not a fit: Patients who are younger than 21 years or do not have conditions related to blood cell production may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve the effectiveness of treatments for conditions requiring blood cell regeneration, such as leukemia or other blood disorders.
How similar studies have performed: Previous research has shown promise in understanding stem cell behavior, but this specific approach using intravital imaging is relatively novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Reizis, Boris — New York University School of Medicine
- Study coordinator: Reizis, Boris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.