Investigating how blood pressure affects Alzheimer's disease in the brain.
Official title: Microanalytical Peptide-Peptidase Profiling of the Brain Renin-Angiotensin System in a Genetically Diverse Alzheimer's Disease Mouse Model
Funded at Univ of Maryland, College Park · NIH-10870915 · Data updated 2026-11-12
This study is looking at how certain brain chemicals related to blood pressure might affect Alzheimer's disease, using mice that represent different human genetics, to help us understand how high blood pressure could influence memory loss and thinking skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $443,365 |
| NIH project number | 1R21AG086859-01 |
| Project ID | NIH-10870915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's disease or those experiencing early signs of cognitive decline.
✕Less likely to help
Patients with non-Alzheimer's forms of dementia or those without any genetic risk factors for Alzheimer's may not benefit from this research.
What this research studies
This research explores the role of the renin-angiotensin system (RAS) in the brain and its connection to Alzheimer's disease (AD) and high blood pressure. Using a genetically diverse mouse model that mimics human AD, the study will analyze brain peptides and enzymes related to blood pressure regulation. The researchers will measure how these factors influence the development and progression of Alzheimer's, particularly focusing on different genetic backgrounds and the effects of hypertension. Advanced data analysis techniques will be employed to uncover complex relationships between brain chemistry and cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting blood pressure regulation to slow or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of the renin-angiotensin system in cardiovascular and neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
Univ of Maryland, College Park
College Park, United States Active
Researchers
- Principal investigator: Nemes, Peter — Univ of Maryland, College Park
- Study coordinator: Nemes, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.