Investigating how blood platelets contribute to bowel injury in premature infants
Official title: Targeting the Thromboinflammatory Response to Mitigate Bowel Injury in Necrotizing Enterocolitis
Funded at State University New York Stony Brook · NIH-10840235 · Data updated 2026-11-12
This study is looking at how certain blood components might affect a serious condition called necrotizing enterocolitis (NEC) in premature babies, with the hope of finding new ways to help improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | August 7, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $239,250 |
| NIH project number | 1R56HD112046-01 |
| Project ID | NIH-10840235 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants diagnosed with necrotizing enterocolitis.
✕Less likely to help
Patients who are not premature infants or those without a diagnosis of necrotizing enterocolitis may not benefit from this research.
What this research studies
This research focuses on necrotizing enterocolitis (NEC), a serious condition affecting premature infants that can lead to severe bowel damage. The study aims to understand the role of blood platelets and a specific protein called Von Willebrand Factor in the inflammation and injury associated with NEC. By using animal models, researchers will explore how these factors contribute to the disease's progression and severity. The ultimate goal is to identify potential therapeutic targets that could improve outcomes for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce bowel injury and improve survival rates in premature infants with NEC.
How similar studies have gone: While the specific approach of targeting the platelet-VWF axis in NEC is novel, similar research has shown promise in understanding thromboinflammatory responses in other conditions.
Where this research is happening
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State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Diacovo, Thomas G — State University New York Stony Brook
- Study coordinator: Diacovo, Thomas G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.