Investigating how blood platelets contribute to bowel injury in premature infants
Targeting the Thromboinflammatory Response to Mitigate Bowel Injury in Necrotizing Enterocolitis
This study is looking at how certain blood components might affect a serious condition called necrotizing enterocolitis (NEC) in premature babies, with the hope of finding new ways to help improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10840235 on NIH RePORTER |
What this research studies
This research focuses on necrotizing enterocolitis (NEC), a serious condition affecting premature infants that can lead to severe bowel damage. The study aims to understand the role of blood platelets and a specific protein called Von Willebrand Factor in the inflammation and injury associated with NEC. By using animal models, researchers will explore how these factors contribute to the disease's progression and severity. The ultimate goal is to identify potential therapeutic targets that could improve outcomes for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants diagnosed with necrotizing enterocolitis.
Not a fit: Patients who are not premature infants or those without a diagnosis of necrotizing enterocolitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce bowel injury and improve survival rates in premature infants with NEC.
How similar studies have performed: While the specific approach of targeting the platelet-VWF axis in NEC is novel, similar research has shown promise in understanding thromboinflammatory responses in other conditions.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Diacovo, Thomas G — State University New York Stony Brook
- Study coordinator: Diacovo, Thomas G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.