Investigating how blood flow in brain veins affects dementia
Brain Drain: In Vivo Optical Interrogation of Venular Function in Gray and White Matter
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-11212205
This study is looking at how tiny veins in the brain might affect memory and thinking as we age, especially in people with Alzheimer's disease, to help us understand how changes in these veins can impact brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11212205 on ClinicalTrials.gov |
What this research studies
This research explores the role of cerebral venules, the small veins in the brain, in contributing to dementia, particularly Alzheimer's disease. By utilizing advanced imaging techniques, the study aims to visualize and understand how age-related changes in these venules impact blood flow in critical areas of the brain. The research focuses on deep gray and white matter, which are essential for cognitive function, and seeks to uncover the mechanisms behind venous drainage impairment. This could lead to new insights into the vascular contributions to cognitive impairment and dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing cognitive impairment or dementia.
Not a fit: Patients with non-age-related cognitive impairments or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for dementia-related conditions.
How similar studies have performed: While the focus on venular pathology in dementia is less explored, similar imaging techniques have shown promise in understanding vascular contributions to other neurological conditions.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIH, ANDY Y — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: SHIH, ANDY Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease