Investigating how blood flow affects exercise in heart failure patients
Official title: The role of alpha-adrenergic vasoconstriction on blood flow to exercising skeletal muscle in patients with heart failure with preserved ejection fraction
Funded at VA Salt Lake City Healthcare System · NIH-11051005 · Data updated 2026-11-12
This study is looking at how certain blood vessel responses affect blood flow to muscles when people with heart failure (HFpEF) exercise, with the goal of finding ways to help them feel better and exercise more easily.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| NIH project number | 1IK1CX002567-01A2 |
| Project ID | NIH-11051005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with heart failure with preserved ejection fraction (HFpEF), particularly veterans.
✕Less likely to help
Patients with heart failure with reduced ejection fraction (HFrEF) may not benefit from this research as it specifically targets HFpEF.
What this research studies
This research focuses on understanding how alpha-adrenergic vasoconstriction impacts blood flow to skeletal muscles during exercise in patients with heart failure with preserved ejection fraction (HFpEF). The study aims to explore the mechanisms behind exercise intolerance, a common and debilitating symptom in these patients. By examining the physiological responses during aerobic activities, the research seeks to identify potential new treatment strategies that could enhance exercise capacity and overall quality of life for individuals with HFpEF.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that enhance exercise capacity and quality of life for patients with heart failure.
How similar studies have gone: While there is extensive literature on heart failure with reduced ejection fraction, research specifically targeting HFpEF and its unique pathophysiology is still emerging, indicating a novel approach.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Alpenglow, Jeremy K — VA Salt Lake City Healthcare System
- Study coordinator: Alpenglow, Jeremy K
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.