Investigating how blood flow affects exercise in heart failure patients
The role of alpha-adrenergic vasoconstriction on blood flow to exercising skeletal muscle in patients with heart failure with preserved ejection fraction
This study is looking at how certain blood vessel responses affect blood flow to muscles when people with heart failure (HFpEF) exercise, with the goal of finding ways to help them feel better and exercise more easily.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11051005 on NIH RePORTER |
What this research studies
This research focuses on understanding how alpha-adrenergic vasoconstriction impacts blood flow to skeletal muscles during exercise in patients with heart failure with preserved ejection fraction (HFpEF). The study aims to explore the mechanisms behind exercise intolerance, a common and debilitating symptom in these patients. By examining the physiological responses during aerobic activities, the research seeks to identify potential new treatment strategies that could enhance exercise capacity and overall quality of life for individuals with HFpEF.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with heart failure with preserved ejection fraction (HFpEF), particularly veterans.
Not a fit: Patients with heart failure with reduced ejection fraction (HFrEF) may not benefit from this research as it specifically targets HFpEF.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that enhance exercise capacity and quality of life for patients with heart failure.
How similar studies have performed: While there is extensive literature on heart failure with reduced ejection fraction, research specifically targeting HFpEF and its unique pathophysiology is still emerging, indicating a novel approach.
Where this research is happening
Salt Lake City, United States
- VA Salt Lake City Healthcare System — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Alpenglow, Jeremy K — VA Salt Lake City Healthcare System
- Study coordinator: Alpenglow, Jeremy K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.