Investigating how blood cells protect the brain after delayed treatment for stroke
Official title: The protective function of blood-borne monocytes/macrophages after delayed recanalization in a permanent MCAO rodent model
Funded at Loma Linda University · NIH-10806832 · Data updated 2026-11-12
This study is looking at how certain immune cells in the blood help the brain heal after a stroke caused by blocked blood vessels, especially when treatment is given later than usual, to find better ways to support recovery for stroke patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $441,715 |
| NIH project number | 1R21NS135557-01 |
| Project ID | NIH-10806832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke and are beyond the standard treatment window.
✕Less likely to help
Patients who have not experienced a stroke or those with other types of strokes may not benefit from this research.
What this research studies
This research explores the role of blood-borne monocytes and macrophages in protecting the brain following a stroke caused by blocked blood vessels. Using a rat model, the study examines the effects of delayed recanalization, a procedure to restore blood flow, on brain health and recovery. The researchers aim to understand how these immune cells contribute to healing after a stroke, particularly when treatment is administered beyond the typical time frame. This could lead to new insights into stroke management and recovery.
Why it matters
Potential benefit: If successful, this research could improve treatment options and outcomes for stroke patients who miss the initial treatment window.
How similar studies have gone: Previous studies have shown promising results with delayed recanalization in stroke patients, suggesting that this approach may lead to improved outcomes.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Zhang, John H — Loma Linda University
- Study coordinator: Zhang, John H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.