Investigating how blood cells protect the brain after delayed treatment for stroke
The protective function of blood-borne monocytes/macrophages after delayed recanalization in a permanent MCAO rodent model
['FUNDING_R21'] · LOMA LINDA UNIVERSITY · NIH-10806832
This study is looking at how certain immune cells in the blood help the brain heal after a stroke caused by blocked blood vessels, especially when treatment is given later than usual, to find better ways to support recovery for stroke patients.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOMA LINDA UNIVERSITY (nih funded) |
| Locations | 1 site (Loma Linda, UNITED STATES) |
| Trial ID | NIH-10806832 on ClinicalTrials.gov |
What this research studies
This research explores the role of blood-borne monocytes and macrophages in protecting the brain following a stroke caused by blocked blood vessels. Using a rat model, the study examines the effects of delayed recanalization, a procedure to restore blood flow, on brain health and recovery. The researchers aim to understand how these immune cells contribute to healing after a stroke, particularly when treatment is administered beyond the typical time frame. This could lead to new insights into stroke management and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke and are beyond the standard treatment window.
Not a fit: Patients who have not experienced a stroke or those with other types of strokes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve treatment options and outcomes for stroke patients who miss the initial treatment window.
How similar studies have performed: Previous studies have shown promising results with delayed recanalization in stroke patients, suggesting that this approach may lead to improved outcomes.
Where this research is happening
Loma Linda, UNITED STATES
- LOMA LINDA UNIVERSITY — Loma Linda, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, JOHN H — LOMA LINDA UNIVERSITY
- Study coordinator: ZHANG, JOHN H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.