Investigating how blocking GP130 affects heart function in pigs with pulmonary arterial hypertension
GP130 Antagonism in Porcine RV Pressure Overload
This study is looking at how blocking a protein called GP130 might help improve heart function in pigs with pulmonary arterial hypertension (PAH), which could lead to better treatments for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11085916 on NIH RePORTER |
What this research studies
This research focuses on understanding pulmonary arterial hypertension (PAH), a serious condition that affects the heart and lungs. The study will explore how blocking a specific protein called GP130 can improve heart function in the right ventricle of pigs suffering from this disease. By using advanced techniques, researchers aim to uncover the molecular changes that occur when GP130 is inhibited, which may lead to better treatments for patients with PAH. The findings could provide insights into how to directly target heart dysfunction associated with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who are experiencing right ventricular dysfunction.
Not a fit: Patients with pulmonary arterial hypertension who do not have right ventricular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and survival rates for patients with pulmonary arterial hypertension.
How similar studies have performed: While this approach is novel in targeting GP130 for right ventricular dysfunction, similar studies have shown promise in addressing heart conditions through targeted molecular interventions.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Prins, Kurt W — University of Minnesota
- Study coordinator: Prins, Kurt W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.