Investigating how blocking certain pathways can affect aging in mice
Effects of Genetic and Pharmacological Kynurenine Pathway Suppression on Healthspan, Lifespan, and Cellular Changes Associated with Aging in Mice
['FUNDING_CAREER'] · JOHNS HOPKINS UNIVERSITY · NIH-11063277
This study is looking at how blocking a specific pathway related to aging and inflammation might help mice live healthier and longer lives, and the results could lead to new ways to improve health in older people.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11063277 on ClinicalTrials.gov |
What this research studies
This research explores the effects of suppressing the kynurenine pathway, which is linked to aging and chronic inflammation, on the health and lifespan of mice. By examining both genetic and pharmacological methods to inhibit this pathway, the study aims to understand how these interventions can influence cellular changes associated with aging. The findings could provide insights into potential treatments that may improve healthspan and longevity in older populations. The research utilizes a combination of laboratory techniques and animal models to gather data on the impacts of these interventions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be older adults experiencing chronic inflammation or age-related health issues.
Not a fit: Patients who are not elderly or do not have conditions related to chronic inflammation may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing health and longevity in aging populations.
How similar studies have performed: Previous studies have shown that inhibiting the kynurenine pathway can extend lifespan in model organisms, suggesting a promising avenue for further exploration in humans.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WESTBROOK, REYHAN M. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: WESTBROOK, REYHAN M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.