Investigating how blocking certain immune pathways affects asthma and allergic reactions.
Mechanistic clinical trial of blocking the IL-4/13 axis in asthmatics precision phenotyped in an aeroallergen challenge chamber before, during and after receipt of dupilumab
This study is looking at how people with allergic asthma and hay fever react to dust mites and how well different treatments work for them, so if you have these allergies, you might help us learn more about your symptoms and find better ways to manage them!
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11092794 on NIH RePORTER |
What this research studies
This research focuses on understanding the varying severity and treatment responses in individuals with allergic asthma and allergic rhinoconjunctivitis. By utilizing a controlled aeroallergen challenge chamber, researchers will expose participants to house dust mites to observe their symptoms and responses. The study aims to identify different phenotypes of allergic reactions and how they relate to airway inflammation and epithelial integrity. Participants will receive either the treatment or a placebo to assess the effectiveness of blocking the IL-4/13 immune pathways.
Who could benefit from this research
Good fit: Ideal candidates are individuals diagnosed with allergic asthma and allergic rhinoconjunctivitis, particularly those sensitive to house dust mites.
Not a fit: Patients with non-allergic asthma or those not affected by house dust mites may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from allergic asthma and related conditions.
How similar studies have performed: Previous research has shown promise in using similar mechanistic approaches to understand and treat allergic conditions, indicating potential for success in this study.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Ahuja, Sunil K — University of Texas Hlth Science Center
- Study coordinator: Ahuja, Sunil K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.