Investigating how blocking a specific chemokine interaction can help treat colorectal cancer
Targeting CCL20-CCR6 Interactions in Colorectal Cancer
This study is looking at how a specific protein and its partner might help colorectal cancer grow, and it hopes to find new ways to treat the disease by blocking their interaction, which could lead to better outcomes for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11043013 on NIH RePORTER |
What this research studies
This research focuses on the role of the chemokine CCL20 and its receptor CCR6 in the development and progression of colorectal cancer. By studying how these interactions contribute to tumor growth and inflammation, the research aims to explore new treatment strategies that could disrupt this process. The approach includes using animal models to test the effects of blocking CCL20-CCR6 interactions on cancer cell behavior and tumor development. If successful, this could lead to innovative therapies that improve outcomes for patients with colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with advanced or metastatic disease.
Not a fit: Patients with early-stage colorectal cancer or those who are not eligible for intensive therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new treatment options that significantly improve survival rates and quality of life for colorectal cancer patients.
How similar studies have performed: While the specific targeting of CCL20-CCR6 interactions is a novel approach, similar strategies targeting chemokine pathways have shown promise in other cancer types.
Where this research is happening
Boston, United States
- VA Boston Health Care System — Boston, United States (Active)
Researchers
- Principal investigator: Gold, Jason Samuel — VA Boston Health Care System
- Study coordinator: Gold, Jason Samuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.