Investigating how bisphenols affect the blood-brain barrier in Alzheimer's disease
Official title: Bisphenol-Induced Blood-Brain Barrier Dysfunction in Alzheimer’s Disease
Funded at University of Kentucky · NIH-10929407 · Data updated 2026-11-12
This study is looking at how everyday chemicals called bisphenols might affect brain health and contribute to Alzheimer's disease, helping us understand how these substances could be linked to memory problems and offering new ways to protect our cognitive health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $732,100 |
| NIH project number | 5R01NS133250-02 |
| Project ID | NIH-10929407 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with a history of exposure to bisphenols.
✕Less likely to help
Patients who do not have any risk factors for Alzheimer's disease or who have already been diagnosed with advanced stages of the disease may not benefit from this research.
What this research studies
This research focuses on understanding how exposure to bisphenols, common environmental chemicals, may contribute to Alzheimer's disease by causing dysfunction in the blood-brain barrier. The study aims to identify the mechanisms through which these chemicals lead to cognitive decline and the accumulation of amyloid-beta, a protein associated with Alzheimer's. By exploring these pathways, the research seeks to clarify the role of bisphenols as risk factors for Alzheimer's disease, which could help in developing preventive strategies. Patients may benefit from insights into how environmental factors influence their cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating Alzheimer's disease by addressing environmental risk factors.
How similar studies have gone: Previous research has indicated that environmental factors, including endocrine disruptors like bisphenols, can impact cognitive health, suggesting that this approach has potential for success.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Hartz, Anika M.s. — University of Kentucky
- Study coordinator: Hartz, Anika M.s.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.