Investigating how biological sex affects tumor environments and responses to immunotherapy
Official title: Examining the effect of biological sex on the tumor microenvironment and immunotherapy response
Funded at Icahn School of Medicine at Mount Sinai · NIH-11062035 · Data updated 2026-11-12
This study is looking at how the environment around tumors differs between men and women and how that affects how well cancer treatments work, so patients can better understand how their sex might influence their treatment options and results.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $42,363 |
| NIH project number | 3U01CA282114-02S1 |
| Project ID | NIH-11062035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include cancer patients of both sexes who are considering or undergoing immunotherapy.
✕Less likely to help
Patients with non-cancerous conditions or those not receiving immunotherapy may not benefit from this research.
What this research studies
This research examines the differences in tumor microenvironments between males and females and how these differences influence responses to immunotherapy. By analyzing genetic factors that regulate tumor composition, the study aims to enhance the effectiveness of cancer treatments. Patients may benefit from a better understanding of how their biological sex impacts their treatment options and outcomes. The research employs genetic analyses to identify key determinants in the immune response to tumors.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective immunotherapy treatments based on biological sex.
How similar studies have gone: Other research has shown promising results in understanding sex differences in immune responses, indicating that this approach has potential for significant findings.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Brown, Brian D — Icahn School of Medicine at Mount Sinai
- Study coordinator: Brown, Brian D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.