Investigating how biological sex affects tumor environments and responses to immunotherapy
Examining the effect of biological sex on the tumor microenvironment and immunotherapy response
This study is looking at how the environment around tumors differs between men and women and how that affects how well cancer treatments work, so patients can better understand how their sex might influence their treatment options and results.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11062035 on NIH RePORTER |
What this research studies
This research examines the differences in tumor microenvironments between males and females and how these differences influence responses to immunotherapy. By analyzing genetic factors that regulate tumor composition, the study aims to enhance the effectiveness of cancer treatments. Patients may benefit from a better understanding of how their biological sex impacts their treatment options and outcomes. The research employs genetic analyses to identify key determinants in the immune response to tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research include cancer patients of both sexes who are considering or undergoing immunotherapy.
Not a fit: Patients with non-cancerous conditions or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective immunotherapy treatments based on biological sex.
How similar studies have performed: Other research has shown promising results in understanding sex differences in immune responses, indicating that this approach has potential for significant findings.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Brown, Brian D — Icahn School of Medicine at Mount Sinai
- Study coordinator: Brown, Brian D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.