Investigating how biological sex affects recovery from radiation exposure
Official title: Sexual Dimorphism in repair and regeneration after radiation exposure
Funded at Albert Einstein College of Medicine · NIH-11096075 · Data updated 2026-11-12
This study is looking at how being male or female affects how the body heals from radiation injuries, especially in the blood and digestive system, to find better treatments that take these differences into account.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $630,543 |
| NIH project number | 5U01AI183947-02 |
| Project ID | NIH-11096075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced radiation exposure or are at risk of acute radiation syndrome.
✕Less likely to help
Patients who have not been exposed to radiation or do not have conditions related to radiation injury may not benefit from this research.
What this research studies
This research explores how biological sex influences the body's response to radiation injury, particularly focusing on hematopoietic and gastrointestinal acute radiation syndromes. It aims to understand the roles of sex hormones and chromosomes in recovery processes, using a specialized mouse model to assess survival rates and biological responses. By examining differences in immune responses and tissue regeneration between male and female mice, the study seeks to identify potential new treatments that consider these sex-based differences.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for individuals affected by radiation exposure.
How similar studies have gone: While the exploration of sex differences in radiation response is emerging, this specific approach using a four core genotypes mouse model is relatively novel and has not been extensively tested.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Guha, Chandan — Albert Einstein College of Medicine
- Study coordinator: Guha, Chandan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.