Investigating how biological molecules interact and develop antibiotic resistance
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
This study is looking at how certain fats and proteins in bacteria work together, which could help us find new ways to create medicines that fight antibiotic-resistant infections, making it easier for patients to get better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11049027 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex structures and interactions of biological molecules, particularly lipids and proteins, which are crucial for deciphering how pathogenic bacteria develop antibiotic resistance. By employing advanced mass spectrometry techniques, specifically ultraviolet photodissociation, the research aims to provide detailed insights into the molecular organization and functional outcomes of these biomolecules. Patients may benefit from the development of new drugs that can effectively target and inhibit the functions of antibiotic-resistant bacteria. The research will explore the intricate networks of non-covalent interactions that dictate these processes, ultimately aiming to enhance our understanding of drug resistance mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacterial pathogens or those who are not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs that effectively combat antibiotic-resistant infections.
How similar studies have performed: Other research has shown promise in using advanced mass spectrometry techniques to understand biomolecular interactions, indicating that this approach has potential for success.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Brodbelt, Jennifer S. — University of Texas at Austin
- Study coordinator: Brodbelt, Jennifer S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.