Investigating how biological aging affects brain health and Alzheimer's risk
Proteomic aging clock and brain structure, cognitive decline and the risk of Alzheimers Disease and related dementias
This study is looking at how certain proteins in your blood can help us understand aging and predict the risk of developing Alzheimer's and other dementias, using samples collected over 20 years from a diverse group of people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10524658 on NIH RePORTER |
What this research studies
This research aims to develop and validate proteomic aging clocks (PACs) to assess biological aging in individuals before they are clinically diagnosed with Alzheimer's Disease (AD) and related dementias. By analyzing blood samples collected over 20 years from participants in the Atherosclerosis Risk in the Community (ARIC) cohort, the study will explore how these PACs can predict cognitive decline and brain structural changes. The research will also examine the relationship between aging biomarkers and the risk of developing Alzheimer's and other dementias, considering factors such as sex and race.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are currently free of Alzheimer's Disease and related dementias.
Not a fit: Patients who are already diagnosed with Alzheimer's Disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification of individuals at risk for Alzheimer's Disease, allowing for timely interventions.
How similar studies have performed: Other research has shown promise in using biological markers to predict cognitive decline, making this approach both relevant and potentially impactful.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Prizment, Anna — University of Minnesota
- Study coordinator: Prizment, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.