Investigating how bile salts influence glucose metabolism
The Role of Bile Salt Hydrolase in Glucose Metabolism
['FUNDING_OTHER'] · VA SAN DIEGO HEALTHCARE SYSTEM · NIH-11105841
This study is looking at how certain bacteria in our gut change bile acids and how that might help people with diabetes better manage their blood sugar levels.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA SAN DIEGO HEALTHCARE SYSTEM (nih funded) |
| Locations | 1 site (SAN DIEGO, UNITED STATES) |
| Trial ID | NIH-11105841 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between bile acids and glucose metabolism, particularly in adults with diabetes. It aims to understand how gut bacteria modify bile acids and how these changes affect glucose regulation in the body. By using engineered bacteria, the study seeks to identify specific bacterial functions that can improve glucose homeostasis and insulin sensitivity. This innovative approach could lead to new strategies for managing diabetes and related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are diagnosed with diabetes or have abnormal glucose metabolism.
Not a fit: Patients without diabetes or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve glucose control for patients with diabetes.
How similar studies have performed: Previous studies have shown promising results in understanding the role of gut microbiota in glucose metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN DIEGO, UNITED STATES
- VA SAN DIEGO HEALTHCARE SYSTEM — SAN DIEGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZARRINPAR, AMIR — VA SAN DIEGO HEALTHCARE SYSTEM
- Study coordinator: ZARRINPAR, AMIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus