Investigating how bile acid receptors help prevent injury in patients with short bowel syndrome
Role of bile acid receptors FXR and TGR5 in preventing injury in short bowel syndrome
This study is looking at how certain bile acid receptors might help people with Short Bowel Syndrome feel better and reduce liver and gut problems caused by their feeding treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10918264 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of bile acid receptors, specifically FXR and TGR5, in patients suffering from Short Bowel Syndrome (SBS). SBS occurs when a significant portion of the intestine is removed, leading to nutritional deficiencies that often require intravenous feeding. The study aims to explore how activating these receptors can help mitigate liver and gut injuries associated with Total Parenteral Nutrition (TPN), which is commonly used in SBS patients. By examining the signaling pathways involved, the research seeks to identify potential therapeutic targets that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Short Bowel Syndrome who rely on Total Parenteral Nutrition for their nutritional needs.
Not a fit: Patients who have not undergone bowel resection or do not have Short Bowel Syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the harmful effects of TPN and improve the quality of life for patients with short bowel syndrome.
How similar studies have performed: Previous studies have shown promising results in understanding the role of bile acids in gut health, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Jain, Ajay K. — Saint Louis University
- Study coordinator: Jain, Ajay K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.