Investigating how beta- and gamma-synucleins affect alpha-synuclein's function in the brain
The Impact of Beta- and Gamma-Synucleins on Alpha-Synuclein's Synaptic Function
This study is looking at how certain proteins in the brain, including one linked to diseases like Alzheimer's and Parkinson's, work together and affect brain cell communication, which could help us find new ways to prevent or treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10694590 on NIH RePORTER |
What this research studies
This research explores the roles of beta-synuclein and gamma-synuclein in the brain, particularly how they interact with alpha-synuclein, a protein linked to neurodegenerative diseases like Alzheimer's and Parkinson's. By studying these interactions, the research aims to understand how they affect neurotransmitter release and neuronal activity. The methodology involves assessing the effects of these proteins on synaptic functions in animal models, which could provide insights into the mechanisms behind these diseases. Patients may benefit from findings that could lead to new prevention or treatment strategies for Alzheimer's and related dementias.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with neurodegenerative diseases not related to synucleinopathies may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease and related dementias.
How similar studies have performed: Other research has shown promising results in understanding synuclein interactions, suggesting potential for breakthroughs in treatment.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Burre, Jacqueline — Weill Medical Coll of Cornell Univ
- Study coordinator: Burre, Jacqueline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.