Investigating how beta-2 adrenergic signaling affects immune system balance and recovery.
Beta-2 adrenergic signaling in immune homeostasis and reconstitution
This study is looking at how certain receptors in the immune system might affect the way immune cells work, especially in people with autoimmune diseases, and it hopes to find new treatment ideas that could help patients recover better after stem cell transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11061102 on NIH RePORTER |
What this research studies
This research explores the role of beta-2 adrenergic receptors in the immune system, particularly how they influence the development and function of immune cells. By studying mouse models, the researchers aim to understand how abnormalities in these receptors can lead to autoimmune diseases. The project will focus on the effects of beta-2 adrenergic signaling on T cell development and myeloid cell responses, especially during immune recovery after stem cell transplants. Patients may benefit from insights that could lead to new treatments for autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or those undergoing hematopoietic cell transplantation.
Not a fit: Patients with non-autoimmune conditions or those not undergoing immune-related treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases and improving immune recovery after transplants.
How similar studies have performed: Previous research has shown that targeting adrenergic signaling can influence immune responses, suggesting potential for success in this area.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Cao, Xuefang — University of Maryland Baltimore
- Study coordinator: Cao, Xuefang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.