Investigating how benzodiazepines affect HIV reservoirs in the brain
Benzodiazepine mediated mechanisms of transcriptional semi-quiescence in discrete myeloid populations
['FUNDING_R01'] · DREXEL UNIVERSITY · NIH-10867350
This study is looking at how HIV can stick around in the brain even when people are on treatment, especially focusing on certain immune cells that might help keep the virus alive, particularly in those who use benzodiazepines, with the goal of finding new ways to get rid of the virus for good.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DREXEL UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10867350 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how HIV persists in the brain despite treatment with antiretroviral therapy. It specifically examines the role of myeloid cells, such as macrophages and microglia, which can harbor the virus and contribute to ongoing inflammation. The study aims to uncover the transcriptional and epigenetic mechanisms that allow these cells to maintain HIV infection, particularly in individuals who use benzodiazepines. By analyzing these processes, the research seeks to identify potential targets for therapies that could eliminate these viral reservoirs.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are also using benzodiazepines or have a history of substance use disorders.
Not a fit: Patients who are not living with HIV or who do not have a history of substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eradicating HIV from the central nervous system, improving health outcomes for people living with HIV.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown promise in targeting viral reservoirs in other contexts, indicating potential for success.
Where this research is happening
PHILADELPHIA, UNITED STATES
- DREXEL UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GASKILL, PETER JESSE — DREXEL UNIVERSITY
- Study coordinator: GASKILL, PETER JESSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus