Investigating how BCL10 mutations affect lymphoma development and treatment response
Role of BCL10 somatic mutations in lymphomagenesis and response to BCR-targeted therapies
This study is looking at how changes in a gene called BCL10 affect the way diffuse large B-cell lymphoma (DLBCL) develops and responds to treatments, with the goal of finding better, personalized treatment options for patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10878000 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of BCL10 mutations in the development of diffuse large B-cell lymphoma (DLBCL) and how these mutations influence responses to targeted therapies. By analyzing genetic profiles of patients with DLBCL, the study aims to identify specific subtypes of the disease that are associated with BCL10 mutations. The researchers will explore the mechanisms by which these mutations contribute to lymphoma progression and treatment outcomes, potentially leading to more personalized treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with diffuse large B-cell lymphoma, particularly those with BCL10 mutations.
Not a fit: Patients with other types of lymphoma or those without BCL10 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with specific subtypes of lymphoma.
How similar studies have performed: Previous research has shown promising results in understanding genetic mutations in lymphomas, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Cerchietti, Leandro C — Weill Medical Coll of Cornell Univ
- Study coordinator: Cerchietti, Leandro C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.