Investigating how basal cells contribute to lung repair after viral infections
Basal cells in airway and alveolar remodeling
This study is looking at how certain cells in the lungs help with healing after viral infections like the flu, using mice to learn more about how these cells can improve lung recovery and possibly lead to better treatments for people with lung issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11083068 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of basal cells in the lungs during the recovery from acute respiratory viral infections, such as H1N1 influenza. It uses mouse models to explore how these infections lead to abnormal lung repair processes, inflammation, and remodeling of small airways and alveoli. The study aims to identify the mechanisms by which basal cells are recruited to damaged areas of the lung and how they affect the behavior of other lung cells involved in repair. By examining these processes, the research seeks to uncover potential therapeutic targets for improving lung function in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe respiratory viral infections and are facing challenges in lung recovery.
Not a fit: Patients with chronic lung diseases unrelated to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung repair and function in patients recovering from severe respiratory infections.
How similar studies have performed: Previous research has shown promising results in understanding lung repair mechanisms, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Stripp, Barry R — Cedars-Sinai Medical Center
- Study coordinator: Stripp, Barry R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.