Investigating how bacterial genetics affect tuberculosis treatment responses
Gerome Wide Association Study of Bacterial Determinants of Clinical Response in Tuberculosis
This study is looking at how certain genetic changes in the bacteria that cause tuberculosis can affect how well patients respond to treatment, with the goal of helping doctors find the right treatment faster for people in Peru and Mongolia who have different reactions to TB therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10595537 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic mutations in Mycobacterium tuberculosis (MTB) influence patient responses to tuberculosis (TB) treatment. By identifying these mutations, the study aims to improve diagnostic tools that can quickly detect drug-resistant strains of TB. This could enable healthcare providers to tailor treatment plans more effectively, potentially leading to better patient outcomes. The research will be conducted in Peru and Mongolia, involving patients with varying responses to TB therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those who have experienced sub-optimal responses to standard treatment.
Not a fit: Patients who do not have tuberculosis or those who have already responded well to standard TB treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for tuberculosis patients, improving their chances of recovery.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to drug resistance in tuberculosis, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Murray, Megan B — Harvard Medical School
- Study coordinator: Murray, Megan B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.