Investigating how bacterial condensates affect protein quality control
Official title: Quality control and spatial regulation of bacterial condensates
Funded at University of Michigan at Ann Arbor · NIH-11031665 · Data updated 2026-11-12
This study is looking at how certain clumps of bacteria help organize important chemical reactions and how this relates to proteins not folding correctly, which could help us understand how bacteria keep their proteins working properly.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $109,255 |
| NIH project number | 1K99GM157383-01 |
| Project ID | NIH-11031665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals affected by diseases related to protein misfolding, such as certain neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to protein misfolding or bacterial infections may not benefit from this research.
What this research studies
This research focuses on understanding the role of bacterial condensates in organizing biochemical reactions and their relationship with protein misfolding. By developing experimental frameworks, the research aims to explore how the material state of these condensates influences protein quality control mechanisms in bacteria. The study will assess the distinct properties of dynamic condensates and insoluble aggregates, particularly in relation to their positioning within bacterial cells. This could lead to new insights into how bacteria manage protein folding and function.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of protein misfolding diseases and lead to novel therapeutic strategies.
How similar studies have gone: Previous research has shown promising results in understanding protein quality control mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Hoang, Y — University of Michigan at Ann Arbor
- Study coordinator: Hoang, Y
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.