Investigating how bacteria modify their surface proteins
High Pressure Liquid Chromatography (HPLC) System for Analyzing Bacterial Lipoprotein Biosynthesis and Oxidation
['FUNDING_R01'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-11100179
This study is looking at how certain proteins from bacteria change when they grow in different conditions, like when there's copper around, to better understand how they interact with their surroundings and our immune system.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-11100179 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the structural modifications of bacterial lipoproteins, particularly in the Firmicutes phylum, which are important for their interaction with the environment and immune system. Using advanced techniques like ultra high-pressure liquid chromatography (uHPLC), the study aims to analyze how these proteins are modified based on various growth conditions, including the presence of copper. The research will involve in vitro assays to explore enzyme mechanisms and identify the components involved in these modifications, ultimately shedding light on their physiological roles.
Who could benefit from this research
Good fit: Patients with infections caused by Firmicutes bacteria may benefit from the findings of this research.
Not a fit: Patients with infections caused by non-Firmicutes bacteria are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into bacterial behavior and potentially inform the development of new treatments for bacterial infections.
How similar studies have performed: While the specific approach of using uHPLC for this purpose may be novel, similar studies have successfully advanced our understanding of bacterial protein modifications.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEREDITH, TIMOTHY C. — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: MEREDITH, TIMOTHY C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.