Investigating how bacteria interact in the lungs of cystic fibrosis patients
Official title: The role of secreted factors on polymicrobial interactions between pathogens of the cystic fibrosis airway
Funded at National Cancer Institute · NIH-10712091 · Data updated 2026-11-12
This study is looking at how two types of bacteria that often live in the lungs of people with cystic fibrosis talk to each other and how that affects lung health, with the hope of finding better ways to manage lung infections for those with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Cancer Institute NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| NIH project number | 1FI2GM150430-01 |
| Project ID | NIH-10712091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cystic fibrosis who experience chronic lung infections.
✕Less likely to help
Patients without cystic fibrosis or those not experiencing polymicrobial lung infections may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between two bacteria, Stenotrophomonas maltophilia and Pseudomonas aeruginosa, which are commonly found in the lungs of patients with cystic fibrosis (CF). The study aims to explore how these bacteria communicate through secreted factors and how this affects their behavior and the overall health of the lung environment. By examining the genetic responses of these bacteria to each other, the research seeks to uncover mechanisms that could influence disease progression in CF patients. This work may lead to new insights into managing lung infections in CF.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating lung infections in cystic fibrosis patients.
How similar studies have gone: Other research has shown promising results in understanding bacterial interactions in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
National Cancer Institute
Bethesda, United States Active
Researchers
- Principal investigator: Katharios-Lanwermeyer, Stefan — National Cancer Institute
- Study coordinator: Katharios-Lanwermeyer, Stefan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.