Investigating how bacteria from the mouth may influence Alzheimer's disease.
Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease
This study is looking at how bacteria from gum disease might be linked to Alzheimer's disease, specifically how certain substances they produce could impact brain health, with the hope of finding new ways to prevent or treat Alzheimer's that could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10828006 on NIH RePORTER |
What this research studies
This research explores the connection between periodontal bacteria and Alzheimer's disease, focusing on how substances produced by these bacteria might affect brain health. The study aims to understand the role of dihydroceramides, a type of lipid, in the development and progression of Alzheimer's. By examining the molecular mechanisms involved, the research seeks to uncover potential pathways linking oral health to cognitive decline. Patients may benefit from insights that could lead to new prevention or treatment strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with a history of periodontal disease.
Not a fit: Patients who do not have any risk factors for Alzheimer's disease or periodontal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for preventing or treating Alzheimer's disease by highlighting the importance of oral health.
How similar studies have performed: While the connection between oral health and Alzheimer's is being explored, this specific approach focusing on dihydroceramides is relatively novel and has not been extensively tested.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Movila, Alexandru — Indiana University Indianapolis
- Study coordinator: Movila, Alexandru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.