Investigating how bacteria-derived compounds may help prevent colon cancer
Official title: Bacteria-derived xenobiotics in colon cancer prevention: Link to GPR109A and colonic ketogenesis
Funded at Augusta University · NIH-10884272 · Data updated 2026-11-12
This study is looking at how certain foods and bacteria in our gut might help protect against colon cancer by interacting with specific receptors in our body, and it hopes to find new ways to boost our natural defenses against this disease, which could lead to helpful dietary tips or treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | July 7, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $398,923 |
| NIH project number | 5R01CA275840-02 |
| Project ID | NIH-10884272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for colon cancer, particularly those with dietary concerns or genetic predispositions.
✕Less likely to help
Patients with advanced colon cancer or those who do not have any risk factors for colon cancer may not benefit from this research.
What this research studies
This research explores the role of dietary chemicals and bacteria-derived compounds in the prevention of colon cancer. It focuses on the interactions between these compounds and specific receptors in the body, particularly GPR109A, which is linked to the regulation of cancer-related proteins. By examining how these interactions affect cancer cell behavior, the research aims to develop new therapeutic strategies that could enhance the body's natural defenses against colon cancer. Patients may benefit from insights into dietary changes or new treatments that could arise from this work.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies or treatments for colon cancer, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for cancer prevention, indicating potential for success in this approach.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Thangaraju, Muthusamy — Augusta University
- Study coordinator: Thangaraju, Muthusamy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.