Investigating how bacteria change shape to survive in different environments
Understanding the mechanisms of intracellular filamentation by bacteria
This study looks at how a specific type of bacteria changes its shape to survive in different environments, especially inside animals, and it aims to understand the genes involved in this process, which could help us learn more about how these bacteria behave and thrive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10890657 on NIH RePORTER |
What this research studies
This research explores how certain bacteria, specifically Bordetella atropi, change their shape to adapt and thrive in various environments, particularly within host animals. By using model organisms like Caenorhabditis elegans, the study examines the genetic mechanisms behind this process, focusing on how bacteria filament and invade host cells. The research aims to uncover the nutrient-sensing pathways that trigger these morphological changes, which could provide insights into bacterial behavior and survival strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by bacteria that exhibit filamentation, particularly those involving Bordetella species.
Not a fit: Patients with non-bacterial infections or those not affected by filamentous bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of bacterial infections and potentially inform new treatment strategies.
How similar studies have performed: While the specific approach of studying filamentation in this context may be novel, similar research has shown that understanding bacterial morphology can lead to significant advancements in treating infections.
Where this research is happening
San Diego, United States
- San Diego State University — San Diego, United States (Active)
Researchers
- Principal investigator: Luallen, Robert J — San Diego State University
- Study coordinator: Luallen, Robert J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.