Investigating how bacteria attach to the urinary tract in kidney infections
Novel Type 1 Pilus Receptors in Pyelonephritis and Recurrent UTI
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11061007
This study is looking at how certain bacteria that cause urinary tract infections stick to the kidneys, and it aims to find ways to stop this from happening, which could help people who suffer from these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11061007 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how uropathogenic Escherichia coli (UPEC) bacteria adhere to the urinary tract, particularly in the kidneys, which can lead to serious infections like pyelonephritis. The study aims to identify specific receptors in kidney cells that these bacteria use to establish infections. By using various genetic and pharmacological methods, researchers will explore the role of a protein called desmoglein-2 in this adhesion process. This could lead to new insights into preventing and treating urinary tract infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who experience recurrent urinary tract infections or pyelonephritis.
Not a fit: Patients with urinary tract infections caused by non-UPEC bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating recurrent urinary tract infections, improving patient outcomes.
How similar studies have performed: Previous research has shown success in understanding bacterial adhesion mechanisms in other contexts, suggesting potential for breakthroughs in this area.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUNSTAD, DAVID — WASHINGTON UNIVERSITY
- Study coordinator: HUNSTAD, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.