Investigating how bacteria attach to surfaces to prevent infections
The Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on Surfaces
['FUNDING_OTHER'] · MISSISSIPPI STATE UNIVERSITY · NIH-11125014
This study is looking at how a common bacteria can stick to surfaces, which can cause infections in hip and knee replacements, and it aims to find ways to stop this from happening, especially using a material often found in medical implants.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MISSISSIPPI STATE UNIVERSITY (nih funded) |
| Locations | 1 site (MISSISSIPPI STATE, UNITED STATES) |
| Trial ID | NIH-11125014 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the bacteria Staphylococcus epidermidis attach to surfaces, which is a critical first step in the formation of biofilms that can lead to infections, particularly in hip and knee replacements. The study examines the binding mechanisms of specific proteins involved in this process and explores ways to inhibit their attachment to surfaces, especially using poly-methylmethacrylate (PMMA), a material commonly used in medical implants. By analyzing how these proteins interact with nanoparticles, the research aims to uncover new strategies to prevent biofilm formation and improve patient outcomes in orthopedic and dental procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing orthopedic or dental procedures involving implants, particularly those at risk for infections.
Not a fit: Patients who do not require implants or are not at risk for biofilm-related infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for preventing infections associated with medical implants, significantly improving patient safety and recovery.
How similar studies have performed: Previous research has shown promise in understanding bacterial attachment and biofilm prevention, indicating that this approach could yield significant advancements.
Where this research is happening
MISSISSIPPI STATE, UNITED STATES
- MISSISSIPPI STATE UNIVERSITY — MISSISSIPPI STATE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FITZKEE, NICHOLAS C — MISSISSIPPI STATE UNIVERSITY
- Study coordinator: FITZKEE, NICHOLAS C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.