Investigating how bacteria and the body respond to treatments that break down biofilms in wound infections
Official title: Bacterial and host response to biofilm dispersal in wound infections
Funded at Texas Tech University Health Scis Center · NIH-10991701 · Data updated 2026-11-12
This study is looking at ways to help treat stubborn infections in chronic wounds by using special agents that can make bacteria, like Pseudomonas aeruginosa, leave their protective layers, so they can be more easily attacked by antibiotics and the body's immune system.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $196,454 |
| NIH project number | 5R21AI175650-02 |
| Project ID | NIH-10991701 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic wounds that are resistant to standard antibiotic treatments.
✕Less likely to help
Patients with acute wounds or those not affected by biofilm-related infections may not benefit from this research.
What this research studies
This research focuses on chronic wound infections caused by biofilms, which protect bacteria from treatment. Researchers will explore the use of biofilm dispersal agents that can encourage bacteria to leave their protective biofilm, making them more vulnerable to antibiotics and the immune system. Using a mouse model, the study will assess the effects of different dispersal strategies on the bacteria Pseudomonas aeruginosa and analyze how these strategies impact both the bacteria and the host's response. The goal is to better understand the risks and benefits of using biofilm dispersal as a treatment for chronic wounds.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic wound infections, improving healing outcomes for patients.
How similar studies have gone: While the use of biofilm dispersal agents is a relatively novel approach, preliminary studies have shown promise in similar contexts, indicating potential for success.
Where this research is happening
-
Texas Tech University Health Scis Center
Lubbock, United States Active
Researchers
- Principal investigator: Rumbaugh, Kendra P — Texas Tech University Health Scis Center
- Study coordinator: Rumbaugh, Kendra P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.