Investigating how B cells respond to HIV vaccines in infants
Core C: B Cell Core
['FUNDING_P01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11059125
This study is looking at how babies' immune systems create special antibodies to fight HIV, by giving infant macaques certain vaccines and tracking how their immune responses develop over time, with the hope of improving future HIV vaccines for young people.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11059125 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the development of broadly neutralizing antibodies (bNAbs) in infants, particularly how their unique immune systems generate diverse antibody responses to HIV. The study will involve immunizing infant macaques with specific HIV vaccine candidates and analyzing the resulting B cell and antibody responses over time. Researchers will utilize advanced techniques like single-cell RNA sequencing to characterize the evolution of these immune responses and their relationship with innate immunity and microbial interactions. The goal is to enhance future HIV vaccine strategies, especially for young populations.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be infants and young children at risk of HIV infection.
Not a fit: Patients who are older than 21 years or those who are not at risk for HIV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved HIV vaccines that are more effective in eliciting strong immune responses in infants.
How similar studies have performed: Previous research has shown promise in understanding B cell responses to HIV, but this specific approach focusing on infants is relatively novel.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE PARIS, KRISTINA — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: DE PARIS, KRISTINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus