Investigating how B cells respond to different antigens
Official title: Core B: Antigen Receptor Sequencing, Cloning, Expression, and Analysis Core
Funded at University of Alabama at Birmingham · NIH-11075846 · Data updated 2026-11-12
This study is looking at how special immune cells called B cells work and change when they encounter things like infections or transplants, which could help improve treatments for people with immune system issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 16, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $434,363 |
| NIH project number | 5U19AI181105-02 |
| Project ID | NIH-11075846 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals undergoing organ transplants or those with autoimmune disorders who may benefit from enhanced understanding of their immune responses.
✕Less likely to help
Patients with stable, non-immune related conditions may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the behavior of B cells, which are crucial components of the immune system that produce antibodies. By analyzing the unique receptors on B cells, researchers aim to track how these cells expand and adapt in response to various antigens, including those from transplants and infections. The study employs advanced sequencing techniques to gather detailed information about B cell receptor diversity and functionality, which could lead to improved treatments for conditions involving immune responses. Patients may benefit from insights gained into how their immune systems react to different challenges.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for managing immune responses in patients, particularly in transplant settings or autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in understanding B cell responses through similar sequencing approaches, indicating a strong potential for success in this area.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: King, Rodney Glenn — University of Alabama at Birmingham
- Study coordinator: King, Rodney Glenn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.