Investigating how B cells interact with T cells in a new model of multiple sclerosis
Official title: Pathogenic B cell:CD4 T cell interactions in a novel B cell-dependent EAE mouse model of multiple sclerosis
Funded at University of Iowa · NIH-10909307 · Data updated 2026-11-12
This study is looking at how certain immune cells called B cells interact with other immune cells in multiple sclerosis, using a special mouse model to help find better treatments for the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $472,369 |
| NIH project number | 5R01AI177594-02 |
| Project ID | NIH-10909307 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those who may benefit from novel B cell-targeted therapies.
✕Less likely to help
Patients with forms of multiple sclerosis that do not involve B cell pathology may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of B cells in multiple sclerosis (MS) by using a novel animal model that emphasizes B cell-dependent mechanisms. The study aims to explore how B cells present antigens to CD4 T cells, which are crucial in the disease process. By examining these interactions, the research seeks to uncover new insights into the pathogenic mechanisms of MS, potentially leading to improved therapies. The approach involves rigorous experimentation with a specially designed mouse model that mimics the disease's characteristics.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting B cell interactions in multiple sclerosis, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown success in understanding B cell roles in autoimmune diseases, but this specific approach using a B cell-dependent model is relatively novel.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Boyden, Alexander — University of Iowa
- Study coordinator: Boyden, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.